1,1'-Carbonyldiimidazole → Imidazole-1-carboxylic acid {4-methyl-5-[2-(1-methyl-cyclopropyl)-pyridin-4-yl]-thiazol-2-yl}amide
反応式
[CH3:1][C:2]1[N:3]=[C:4]([NH2:17])[S:5][C:6]=1[C:7]1[CH:12]=[CH:11][N:10]=[C:9]([C:13]2([CH3:16])[CH2:15][CH2:14]2)[CH:8]=1.[CH:18]1[N:22]=[CH:21][N:20]([C:23](N2C=NC=C2)=[O:24])[CH:19]=1>C(Cl)Cl>[CH3:1][C:2]1[N:3]=[C:4]([NH:17][C:23]([N:20]2[CH:19]=[CH:18][N:22]=[CH:21]2)=[O:24])[S:5][C:6]=1[C:7]1[CH:12]=[CH:11][N:10]=[C:9]([C:13]2([CH3:16])[CH2:15][CH2:14]2)[CH:8]=1参加物
4
実験手順
A mixture of 4-methyl-5-[2-(1-methyl-cyclopropyl)-pyridin-4-yl]-thiazol-2-ylamine (Step 1.2) (28.5 mmol) and CDI (42.8 mmol) in CH2Cl2 (330 mL) was refluxed for 11 h. After cooling to rt, the reaction mixture was filtered to afford the title compound as a light green solid.