Hydrochloric Acid → HCID 57821247、化合物
反応式
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][N:11]([CH2:14][C:15]2[NH:16][C:17](=[O:30])[C:18]3[C:23]([CH3:24])=[C:22]([C:25]([O:27]CC)=[O:26])[S:21][C:19]=3[N:20]=2)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].Cl>[OH-].[Na+]>[C:1]([O:5][C:6]([N:8]1[CH2:9][CH2:10][N:11]([CH2:14][C:15]2[NH:16][C:17](=[O:30])[C:18]3[C:23]([CH3:24])=[C:22]([C:25]([OH:27])=[O:26])[S:21][C:19]=3[N:20]=2)[CH2:12][CH2:13]1)=[O:7])([CH3:4])([CH3:2])[CH3:3]参加物
4
反応条件
- 温度
- 100 °C
実験手順
436 Milligrams of ethyl 2-(4-tert-butoxycarbonylpiperazin-1-ylmethyl)-5-methyl-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-6-carboxylate as synthesized in Production Example 21 was suspended in 4 mL of 0.5N sodium hydroxide and stirred at 100° C. for 2 hours. After cooling off, the reaction liquid was neutralized with 1N hydrochloric acid, and the precipitate was recovered by filtration. Drying the same, 377 mg (92%) of the title compound was obtained.