Dimethylamine, hydrochloride → 3-(5-Dimethylcarbamoyl-pent-1-ynyl)-N-(2-hydroxy-1-methyl-ethyl)benzamide
反応式
[OH:1][CH2:2][CH:3]([NH:5][C:6]([C:8]1[CH:9]=[C:10]([C:14]#[C:15][CH2:16][CH2:17][CH2:18][C:19]([OH:21])=O)[CH:11]=[CH:12][CH:13]=1)=[O:7])[CH3:4].Cl.[CH3:23][NH:24][CH3:25]>>[CH3:23][N:24]([CH3:25])[C:19]([CH2:18][CH2:17][CH2:16][C:15]#[C:14][C:10]1[CH:9]=[C:8]([CH:13]=[CH:12][CH:11]=1)[C:6]([NH:5][CH:3]([CH3:4])[CH2:2][OH:1])=[O:7])=[O:21]参加物
3
実験手順
6-[3-(2-Hydroxy-1-methyl-ethylcarbamoyl)phenyl]-hex-5-ynoic acid (4) (0.109 g, 0.377 mmol) was reacted using method C with dimethylamine hydrochloride to obtain 8 (0.115 g, 0.363 mmol; 96% yield).
後処理
- customto obtain 8 (0.115 g, 0.363 mmol; 96% yield)
出典と根拠
- ORDレコード
- ord-fd2abcfcc7454c37b2620786151b1c20
- 出典データセット
- uspto-grants-2012_10
- 特許番号
- US08293796B2
反応ノート
読み込み中…