Thionyl Chloride → 3-Chloroisonicotinoyl chloride hydrochloride

HRID 2067183ノート

反応式

HRID 2067183 の反応式
[Cl:1][C:2]1[CH:10]=[N:9][CH:8]=[CH:7][C:3]=1[C:4](O)=[O:5].S(Cl)([Cl:13])=O>C1(C)C=CC=CC=1>[ClH:1].[Cl:1][C:2]1[CH:10]=[N:9][CH:8]=[CH:7][C:3]=1[C:4]([Cl:13])=[O:5]

参加物

4

反応物 2

HCID 24386Thionyl ChlorideHCID 27358163-Chloropyridine-4-carboxylic acid

生成物 1

HCID 866418943-Chloroisonicotinoyl chloride hydrochloride

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

反応条件

温度
100 °C

実験手順

To a suspension of 3-chloroisonicotinic acid (750 mg, 4.76 mmol, 1.0 eq) in 25 mL of toluene was added thionyl chloride (3.0 mL, 41.6 mmol, 8.7 eq) at room temperature. The reaction mixture was stirred at 100° C. for 3 hours. The mixture was concentrated under reduced pressure, dissolved in 25 mL of toluene and concentrated again to give crude 3-chloroisonicotinoyl chloride hydrochloride salt, which was used in the next step without further purification.

後処理

  1. concentrationThe mixture was concentrated under reduced pressure
  2. dissolutiondissolved in 25 mL of toluene
  3. concentrationconcentrated again

出典と根拠

ORDレコード
ord-a2dcbbe64fab4a199e4686f9206545c4
出典データセット
uspto-grants-2012_10
特許番号
US08293769B2

反応ノート

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