Triphenylphosphine → HCID 55283830、化合物

HRID 2067339ノート

反応式

HRID 2067339 の反応式
[N:1]([CH2:4][C:5]1[O:6][C:7]([CH:10]([F:12])[F:11])=[CH:8][CH:9]=1)=[N+]=[N-].C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1>O1CCCC1.O>[F:11][CH:10]([F:12])[C:7]1[O:6][C:5]([CH2:4][NH2:1])=[CH:9][CH:8]=1

参加物

5

反応物 2

HCID 11776TriphenylphosphineHCID 866452892-(Azidomethyl)-5-(difluoromethyl)furan

生成物 1

HCID 55283830HCID 55283830、化合物収率 70%

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 8028Tetrahydrofuran溶媒

実験手順

To a solution of 2-(azidomethyl)-5-(difluoromethyl)furan (0.50 g, 2.92 mmol) in a mixture of tetrahydrofuran (10 mL) and water (1 mL) was added triphenylphosphine (1.15 g, 4.39 mmol). The reaction mixture was stirred at ambient temperature for 18 hours. The solvent was removed in vacuo and the residue was purified on strong cation exchange column to afford (5-(difluoromethyl)furan-2-yl)methanamine as a yellow oil in 70% yield (0.30 g): MS (ES+) m/z 3148.2 (M+1).

後処理

  1. customThe solvent was removed in vacuo
  2. customthe residue was purified on strong cation exchange column

出典と根拠

ORDレコード
ord-1b6348d37c4c4b91ada149611453b441
出典データセット
uspto-grants-2012_10
特許番号
US08293768B2

反応ノート

読み込み中…