Acetic Acid → 2-(Trifluoromethyl)piperazine
反応式
C([N:8]1[CH2:13][CH2:12][NH:11][CH:10]([C:14]([F:17])([F:16])[F:15])[CH2:9]1)C1C=CC=CC=1.CC(O)=O.[H][H]>CO.[Pd]>[F:15][C:14]([F:17])([F:16])[CH:10]1[CH2:9][NH:8][CH2:13][CH2:12][NH:11]1参加物
6
実験手順
1-Benzyl-3-(trifluoromethyl)piperazine 34a (4.1 mmol) is dissolved in MeOH (50 mL) followed by addition of AcOH (2.0 mL) and 5% mol of Pd/C. The flask is charged with a hydrogen balloon and stirred for 12 h. The mixture is filtered over celite and the filtrate is concentrated to afford 2-(trifluoromethyl)piperazine 35a, which is used without further purification. MS (m/z) (M+1)+: 155.1.
後処理
- filtrationThe mixture is filtered over celite
- concentrationthe filtrate is concentrated
出典と根拠
- ORDレコード
- ord-f4879ccdb1af424b8a6eb3850d31706d
- 出典データセット
- uspto-grants-2012_10
- 特許番号
- US08293757B2
反応ノート
読み込み中…