Sodium Hydroxide → Ertapenem disodium

HRID 2068128ノート

反応式

HRID 2068128 の反応式
[CH3:1][C@H:2]1[C:9]([S:10][C@@H:11]2[CH2:15][NH:14][C@H:13]([C:16]([NH:18][C:19]3[CH:20]=[CH:21][CH:22]=[C:23]([C:25]([OH:27])=[O:26])[CH:24]=3)=[O:17])[CH2:12]2)=[C:8]([C:28]([OH:30])=[O:29])[N:7]2[C@H:3]1[C@@H:4]([C@H:31]([OH:33])[CH3:32])[C:5]2=[O:6].[Na].[OH-].[Na+:36]>C(=O)(O)[O-].[Na+]>[CH3:1][C@H:2]1[C:9]([S:10][C@@H:11]2[CH2:15][NH:14][C@H:13]([C:16]([NH:18][C:19]3[CH:24]=[C:23]([C:25]([O-:27])=[O:26])[CH:22]=[CH:21][CH:20]=3)=[O:17])[CH2:12]2)=[C:8]([C:28]([O-:30])=[O:29])[N:7]2[C@H:3]1[C@@H:4]([C@H:31]([OH:33])[CH3:32])[C:5]2=[O:6].[Na+:36].[Na+:36]

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 665981361-Azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid,3-[[(3S,5S)-5-[[(3-carboxyphenyl)amino]carbonyl]-3-pyrrolidinyl]thio]-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-, monosodium salt, (4R,5S,6S)-

生成物 1

HCID 150611Ertapenem disodium

試薬・触媒・溶媒 1

HCID 516892Sodium Bicarbonate溶媒

実験手順

To the solution of sodium bicarbonate (2.5 g in 70 mL water) Ertapenem monosodium (15 g) was slowly added at 0-5° C., by maintaining pH around 7.5 using sodium hydroxide solution. The solution obtained was subjected to carbon treatment, followed by stirred with alumina and filtered. To filtrate, containing Ertapenem disodium was filtered through 0.2 micron filter paper and added into 2500 mL of cold IPA solution at 0-5° C. The solid obtained was filtered washed with IPA followed by acetone and IPE, dried under dry and wet nitrogen to yield Ertapenem disodium (Yield—8-12 g; sodium content: 9.2-10.5%; moisture content: 5-7%; pH: 7.5-8.0). The color of the reconstituted product was pale yellow.

後処理

  1. temperatureby maintaining pH around 7.5
  2. customThe solution obtained
  3. filtrationfiltered
  4. additionTo filtrate, containing Ertapenem disodium
  5. filtrationwas filtered through 0.2 micron
  6. filtrationfilter paper
  7. additionadded into 2500 mL of cold IPA solution at 0-5° C
  8. customThe solid obtained
  9. filtrationwas filtered
  10. washwashed with IPA
  11. customdried
  12. customunder dry

出典と根拠

ORDレコード
ord-25eb0003c4a14a91b78c164bc984c6a8
出典データセット
uspto-grants-2012_10
特許番号
US08293924B2

反応ノート

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