Lithium Hydroxide → 1-[(4-Ethoxybenzoyl)amino]cyclopropanecarboxylic acid

HRID 2068551ノート

反応式

HRID 2068551 の反応式
[CH2:1]([O:3][C:4]1[CH:20]=[CH:19][C:7]([C:8]([NH:10][C:11]2([C:14]([O:16]CC)=[O:15])[CH2:13][CH2:12]2)=[O:9])=[CH:6][CH:5]=1)[CH3:2].[OH-].[Li+]>O1CCOCC1.O>[CH2:1]([O:3][C:4]1[CH:5]=[CH:6][C:7]([C:8]([NH:10][C:11]2([C:14]([OH:16])=[O:15])[CH2:12][CH2:13]2)=[O:9])=[CH:19][CH:20]=1)[CH3:2]

参加物

5

反応物 2

HCID 3939Lithium HydroxideHCID 58304093Ethyl 1-[(4-ethoxybenzoyl)amino]cyclopropanecarboxylate

生成物 1

HCID 583041121-[(4-Ethoxybenzoyl)amino]cyclopropanecarboxylic acid収率 73.3%

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 312751,4-Dioxane溶媒

実験手順

Dissolve ethyl 1-[(4-ethoxybenzoyl)amino]cyclopropanecarboxylate (4.25 g, 15.33 mmol) in 1,4-dioxane (60 mL) and add lithium hydroxide (LiOH) (3.22 g, 76.63 mmol) dissolved in water (30 mL). Stir the reaction for approximately 16 hours at ambient temperature. Concentrate the mixture under reduced pressure, add water, acidify with 5N HCl, and collect the precipitate by filtration to give the title compound (2.8 g, 73%) as a white solid: MS (m/z): 248 (M+1).

後処理

  1. customthe reaction for approximately 16 hours at ambient temperature
  2. concentrationConcentrate the mixture under reduced pressure
  3. additionadd water
  4. customcollect the precipitate
  5. filtrationby filtration

出典と根拠

ORDレコード
ord-11393c99d8094dba931f8a16b0bc4940
出典データセット
uspto-grants-2012_10
特許番号
US08299061B2

反応ノート

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