Benzyl Alcohol → 6-(Benzyloxy)-8-bromoisoquinoline

HRID 2069083ノート

反応式

HRID 2069083 の反応式
[CH2:1]([OH:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.CN(C(/N=N/C(N(C)C)=O)=O)C.[Br:40][C:41]1[CH:42]=[C:43](O)[CH:44]=[C:45]2[C:50]=1[CH:49]=[N:48][CH:47]=[CH:46]2>C1(C)C=CC=CC=1>[CH2:1]([O:8][C:43]1[CH:44]=[C:45]2[C:50](=[C:41]([Br:40])[CH:42]=1)[CH:49]=[N:48][CH:47]=[CH:46]2)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

6

反応物 4

HCID 244Benzyl AlcoholHCID 11776TriphenylphosphineHCID 5353800DiamideHCID 1357421998-Bromoisoquinolin-6-ol

生成物 1

HCID 674026996-(Benzyloxy)-8-bromoisoquinoline

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

Benzyl alcohol (0.25 mL; Ald), triphenylphosphine (1.29 g), and TMAD (850 mg; Ald) were added to a toluene (30 mL) solution of Intermediate 7 (500 mg) and the resulting mixture was stirred at room temperature for 13 hours. The reaction mixture solution was filtrated, the solvent was evaporated under reduced pressure, and the residue was purified by column chromatography (Yamazen; n-hexane/ethyl acetate) to give the title compound (186 mg).

後処理

  1. filtrationThe reaction mixture solution was filtrated
  2. customthe solvent was evaporated under reduced pressure
  3. customthe residue was purified by column chromatography (Yamazen; n-hexane/ethyl acetate)

出典と根拠

ORDレコード
ord-1873497c12c84a3685fd0a06d7ac0774
出典データセット
uspto-grants-2012_10
特許番号
US08299055B2

反応ノート

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