Hydrazine hydrate (1:1) → 4-(3-Dimethylaminopyrrolidin-1-yl)benzohydrazide

HRID 2069319ノート

反応式

HRID 2069319 の反応式
[CH3:1][N:2]([CH3:19])[CH:3]1[CH2:7][CH2:6][N:5]([C:8]2[CH:18]=[CH:17][C:11]([C:12](OCC)=[O:13])=[CH:10][CH:9]=2)[CH2:4]1.O.[NH2:21][NH2:22]>C(O)C>[CH3:1][N:2]([CH3:19])[CH:3]1[CH2:7][CH2:6][N:5]([C:8]2[CH:18]=[CH:17][C:11]([C:12]([NH:21][NH2:22])=[O:13])=[CH:10][CH:9]=2)[CH2:4]1

参加物

4

反応物 2

HCID 24654Hydrazine hydrate (1:1)HCID 69209289Ethyl 4-(3-dimethylaminopyrrolidin-1-yl)benzoate

生成物 1

HCID 692131084-(3-Dimethylaminopyrrolidin-1-yl)benzohydrazide

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

反応条件

温度
5 °C

実験手順

A mixture of ethyl 4-(3-dimethylaminopyrrolidin-1-yl)benzoate (2.0 g), hydrazine hydrate (3.8 g) and ethanol (7 ml) was boiled under reflux for 15 hours. After cooling to 5° C., the resulting precipitate was filtered off with suction. The product with the molecular weight of 248.33 (C13H20N4O) was obtained in this way; MS (ESI): 249 (M+H+).

後処理

  1. temperatureunder reflux for 15 hours
  2. filtrationthe resulting precipitate was filtered off with suction
  3. customThe product with the molecular weight of 248.33 (C13H20N4O) was obtained in this way

出典と根拠

ORDレコード
ord-5a516f4aadef42b6a42ec5bb47a12261
出典データセット
uspto-grants-2012_10
特許番号
US08299104B2

反応ノート

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