(E)-ethyl 3-(5-hydroxy-[1,1'-biphenyl]-2-yl)acrylate → Ethyl 3-(5-hydroxy-[1,1'-biphenyl]-2-yl)propanoate

HRID 2069637

反応式

HRID 2069637 の反応式
[OH:1][C:2]1[CH:3]=[CH:4][C:5](/[CH:14]=[CH:15]/[C:16]([O:18][CH2:19][CH3:20])=[O:17])=[C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[CH:7]=1.[H][H]>C(O)C.[Pd]>[OH:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:14][CH2:15][C:16]([O:18][CH2:19][CH3:20])=[O:17])=[C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[CH:7]=1

参加物

5

反応物 2

HCID 58566652(E)-ethyl 3-(5-hydroxy-[1,1'-biphenyl]-2-yl)acrylateHCID 178418361HCID 178418361、化合物

生成物 1

HCID 58566596Ethyl 3-(5-hydroxy-[1,1'-biphenyl]-2-yl)propanoate

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

To a solution (E)-ethyl 3-(5-hydroxy-[1,1′-biphenyl]-2-yl)acrylate (652) (420 mg, 1.57 mmol) in ethanol (6 mL) was added Pd/C (42 mg, 10% Degussa type). A balloon of hydrogen gas was added and the reaction was evacuated and back-filled with hydrogen three times. The reaction was stirred overnight at room temperature, was filtered through a pad of celite and concentrated in vacuo to give ethyl 3-(5-hydroxy-[1,1′-biphenyl]-2-yl)propanoate (653).

後処理

  1. customthe reaction was evacuated
  2. additionback-filled with hydrogen three times
  3. filtrationwas filtered through a pad of celite
  4. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-3a5b2a2f2de44eb3b1047e593d8ab2fe
出典データセット
uspto-grants-2012_10
特許番号
US08299117B2

関連ノート

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