4-[1-(4-Methoxybenzyl)-1H-pyrazolo[3,4-b]pyridin-4-yloxy]aniline → 4-(1H-pyrazolo[3,4-b]pyridin-4-yloxy)aniline

HRID 2070026ノート

反応式

HRID 2070026 の反応式
COC1C=CC(C[N:8]2[C:12]3=[N:13][CH:14]=[CH:15][C:16]([O:17][C:18]4[CH:24]=[CH:23][C:21]([NH2:22])=[CH:20][CH:19]=4)=[C:11]3[CH:10]=[N:9]2)=CC=1>C(O)(C(F)(F)F)=O>[NH:8]1[C:12]2=[N:13][CH:14]=[CH:15][C:16]([O:17][C:18]3[CH:24]=[CH:23][C:21]([NH2:22])=[CH:20][CH:19]=3)=[C:11]2[CH:10]=[N:9]1

参加物

3

反応物 1

HCID 593985274-[1-(4-Methoxybenzyl)-1H-pyrazolo[3,4-b]pyridin-4-yloxy]aniline

生成物 1

HCID 593985424-(1H-pyrazolo[3,4-b]pyridin-4-yloxy)aniline収率 88%

試薬・触媒・溶媒 1

HCID 6422Trifluoroacetic acid溶媒

反応条件

温度
60 °C

実験手順

4-[1-(4-Methoxybenzyl)-1H-pyrazolo[3,4-b]pyridin-4-yloxy]aniline (263 mg) was dissolved in TFA (7.5 mL). The resulting mixture was stirred at 60° C. for 2 hours and concentrated under reduced pressure. The residue was diluted with dichloromethane and then washed with a sodium bicarbonate solution and saturated brine. The organic layer was separated and concentrated under reduced pressure. The residue was suspended in ether, and the precipitate was collected by filtration to give 4-(1H-pyrazolo[3,4-b]pyridin-4-yloxy)aniline (151 mg, yield: 88%) as a light-brown powder.

後処理

  1. concentrationconcentrated under reduced pressure
  2. additionThe residue was diluted with dichloromethane
  3. washwashed with a sodium bicarbonate solution and saturated brine
  4. customThe organic layer was separated
  5. concentrationconcentrated under reduced pressure
  6. filtrationthe precipitate was collected by filtration

出典と根拠

ORDレコード
ord-83cd822d725c415caa649f5eb6e79c20
出典データセット
uspto-grants-2012_10
特許番号
US08299252B2

反応ノート

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