Sodium borohydride → 3-(4-Nitro-2-(trifluoromethyl)phenyl)propan-1-ol

HRID 2070030

反応式

HRID 2070030 の反応式
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([CH2:10][CH2:11][CH:12]=[O:13])=[C:6]([C:14]([F:17])([F:16])[F:15])[CH:5]=1)([O-:3])=[O:2].[BH4-].[Na+]>CO>[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([CH2:10][CH2:11][CH2:12][OH:13])=[C:6]([C:14]([F:15])([F:16])[F:17])[CH:5]=1)([O-:3])=[O:2]

参加物

4

反応物 2

HCID 4311764Sodium borohydrideHCID 231552963-(4-Nitro-2-(trifluoromethyl)phenyl)propionaldehyde

生成物 1

HCID 593985353-(4-Nitro-2-(trifluoromethyl)phenyl)propan-1-ol収率 50%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

3-(4-Nitro-2-(trifluoromethyl)phenyl)propionaldehyde (1700 mg, 6.9 mmol) was dissolved in methanol (10 mL), and sodium borohydride (100 mg, 2.64 mmol) was added thereto. The mixture was stirred at room temperature for 1 hour. The reaction solution was concentrated under reduced pressure and then purified by silica-gel column chromatography (n-hexane:ethyl acetate=3:1) to give 3-(4-nitro-2-(trifluoromethyl)phenyl)propan-1-ol (859 mg, 50%) as a light-yellow oil.

後処理

  1. concentrationThe reaction solution was concentrated under reduced pressure
  2. custompurified by silica-gel column chromatography (n-hexane:ethyl acetate=3:1)

出典と根拠

ORDレコード
ord-9adc8069790e49a48fb0ac151e097f6f
出典データセット
uspto-grants-2012_10
特許番号
US08299252B2

関連ノート

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