HCID 86649074、化合物 → 3-amino-8-(2-oxopyrrolidin-1-yl)-1-(thiophen-3-ylmethyl)-3,4-dihydroquinolin-2(1H)-one

HRID 2070132ノート

反応式

HRID 2070132 の反応式
C([C@H]([C@@H](C(O)=O)O)O)(O)=O.[NH2:11][CH:12]1[CH2:21][C:20]2[C:15](=[C:16]([N:22]3[CH2:26][CH2:25][CH2:24][C:23]3=[O:27])[CH:17]=[CH:18][CH:19]=2)[N:14]([CH2:28][C:29]2[CH:33]=[CH:32][S:31][CH:30]=2)[C:13]1=[O:34]>C(Cl)(Cl)Cl>[NH2:11][CH:12]1[CH2:21][C:20]2[C:15](=[C:16]([N:22]3[CH2:26][CH2:25][CH2:24][C:23]3=[O:27])[CH:17]=[CH:18][CH:19]=2)[N:14]([CH2:28][C:29]2[CH:33]=[CH:32][S:31][CH:30]=2)[C:13]1=[O:34]

参加物

3

反応物 1

HCID 86649074HCID 86649074、化合物

生成物 1

HCID 596203303-amino-8-(2-oxopyrrolidin-1-yl)-1-(thiophen-3-ylmethyl)-3,4-dihydroquinolin-2(1H)-one収率 86.7%

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒

実験手順

3-Amino-8-(2-oxopyrrolidin-1-yl)-1-(thiophen-3-ylmethyl)-3,4-dihydroquinolin-2(1H)-one D-(−)-tartrate (254 g) was suspended in chloroform (1.3 L), and the suspension was extracted with saturated aqueous sodium bicarbonate solution (1.3 L). The organic layers were combined, and the combined organic layer was dried over sodium sulfate. The solvent was evaporated, and ethyl acetate was added to the thus-recovered residue. The precipitates were recovered through filtration and dried, whereby the title compound (153 g) was yielded.

後処理

  1. extractionthe suspension was extracted with saturated aqueous sodium bicarbonate solution (1.3 L)
  2. dry with materialthe combined organic layer was dried over sodium sulfate
  3. customThe solvent was evaporated
  4. additionethyl acetate was added to the thus-recovered residue
  5. filtrationThe precipitates were recovered through filtration
  6. customdried

出典と根拠

ORDレコード
ord-e51c01dd5fb7485580573724224365c2
出典データセット
uspto-grants-2012_10
特許番号
US08299255B2

反応ノート

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