(2Z)-3-(2-cyanophenyl)prop-2-enoic acid → 3-(2-Cyanophenyl)propanoic acid

HRID 2070833

反応式

HRID 2070833 の反応式
[C:1]([C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1/[CH:9]=[CH:10]\[C:11]([OH:13])=[O:12])#[N:2].[H][H]>C(O)C.[Pd]>[C:1]([C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[CH2:9][CH2:10][C:11]([OH:13])=[O:12])#[N:2]

参加物

5

反応物 2

HCID 1899166(2Z)-3-(2-cyanophenyl)prop-2-enoic acidHCID 178418361HCID 178418361、化合物

生成物 1

HCID 123988503-(2-Cyanophenyl)propanoic acid収率 90.7%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒2 回

実験手順

A slurry of (Z)-3-(2-cyanophenyl)acrylic acid (Example 323a, 4.75 g) in ethanol (50 mL) was added to 5% Palladium (0.292 g) in ethanol (50 mL) and hydrogenated under 2.0 bar hydrogen pressure for 2 h. The reaction mixture was filtered and the filtrate evaporated to dryness to afford the sub title compound as a solid (4.36 g).

後処理

  1. filtrationThe reaction mixture was filtered
  2. customthe filtrate evaporated to dryness

出典と根拠

ORDレコード
ord-a001d97a0f734b7f966d398a04be9278
出典データセット
uspto-grants-2012_10
特許番号
US08299246B2

関連ノート

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