2-(Azidomethyl)benzofuran → 2-(Aminomethyl)benzofuran
反応式
[N:1]([CH2:4][C:5]1[O:6][C:7]2[CH:13]=[CH:12][CH:11]=[CH:10][C:8]=2[CH:9]=1)=[N+]=[N-]>CO.[OH-].[OH-].[Pd+2]>[O:6]1[C:7]2[CH:13]=[CH:12][CH:11]=[CH:10][C:8]=2[CH:9]=[C:5]1[CH2:4][NH2:1]参加物
4
実験手順
A mixture of 2-(azidomethyl)benzofuran and 267 mg of 20% Pd(OH)2 in 10 mL of MeOH was stirred at r.t. under H2 balloon for 2.5 h. The mixture was filtered through Celite and concentrated to give the crude benzofuran-2-ylmethanamine which was used without further purification.
後処理
- filtrationThe mixture was filtered through Celite
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-dfb824ff00a045259c508633e6f36e4f
- 出典データセット
- uspto-grants-2012_10
- 特許番号
- US08299267B2
反応ノート
読み込み中…