Acetic Anhydride → HCID 59570155、化合物
反応式
[OH:1][C:2]1[CH:3]=[C:4]([CH:7]=[C:8]([CH:10]([CH3:12])[CH3:11])[CH:9]=1)[CH:5]=[O:6].[CH3:13][C:14](OC(C)=O)=[O:15]>N1C=CC=CC=1>[C:14]([O:1][C:2]1[CH:9]=[C:8]([CH:10]([CH3:12])[CH3:11])[CH:7]=[C:4]([CH:5]=[O:6])[CH:3]=1)(=[O:15])[CH3:13]参加物
4
実験手順
A solution of 33.2 mg (0.202 mmol) of 3-hydroxy-5-isopropylbenzaldehyde and 50 μL (0.53 mmol) of Ac2O in 3 mL of pyridine was stirred at r.t. for 70 min. The solution was concentrated, water and EtOAc were added, and the layers were separated. The organic layer was washed with brine, dried over Na2SO4, filtered, concentrated, and purified by flash silica gel chromatography (20% EtOAc/hexanes) (neutral silica gel) to provide 47.4 mg of 3-formyl-5-isopropylphenyl acetate as a yellow oil with some impurity.
後処理
- concentrationThe solution was concentrated
- additionwater and EtOAc were added
- customthe layers were separated
- washThe organic layer was washed with brine
- dry with materialdried over Na2SO4
- filtrationfiltered
- concentrationconcentrated
- custompurified by flash silica gel chromatography (20% EtOAc/hexanes) (neutral silica gel)
出典と根拠
- ORDレコード
- ord-a945496c276f4534b48ffed1bc2ea1bc
- 出典データセット
- uspto-grants-2012_10
- 特許番号
- US08299267B2
反応ノート
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