HCID 12736928、化合物 → HCID 12736931、化合物
反応式
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[O:14][C:13]3[C:12](=[O:15])[CH:11]=[C:10]([C:16]([O:18]C)=[O:17])[NH:9][C:8]=3[C:7](=[O:20])[C:6]=2[CH:21]=1>[OH-].[Na+]>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[O:14][C:13]3[C:12](=[O:15])[CH:11]=[C:10]([C:16]([OH:18])=[O:17])[NH:9][C:8]=3[C:7](=[O:20])[C:6]=2[CH:21]=1参加物
3
実験手順
A suspension of methyl 8-chloro-4,10-dihydro-4,10-dioxo-1H-1-benzopyrano[3,2-b]pyridine-2-carboxylate (1 g, 0.0034 mole) in 1N sodium hydroxide solution (20 ml) was stirred at room temperature for 24 hrs. The solid was filtered off, washed with water, with acetone, and suspended in 5N hydrochloric acid. The product was filtered off, washed with water, with acetone, and sucked dry. Recrystallization from DMF gave white crystals (0.775 g, 81%), m.p. 290°-320° (dec.).
後処理
- filtrationThe solid was filtered off
- washwashed with water, with acetone
- filtrationThe product was filtered off