9,9-Dimethyl-9,10-dihydroacridine → 9,9-Dimethyl-10-(5-methyl-1-pyrrolin-2-YL)acridan

HRID 2071406

反応式

HRID 2071406 の反応式
[CH3:1][C:2]1([CH3:16])[C:15]2[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=2[NH:9][C:8]2[C:3]1=[CH:4][CH:5]=[CH:6][CH:7]=2.[CH3:17][CH:18]1[NH:22][C:21](=O)[CH2:20][CH2:19]1.P(Cl)(Cl)(Cl)=O>>[CH3:1][C:2]1([CH3:16])[C:3]2[CH:4]=[CH:5][CH:6]=[CH:7][C:8]=2[N:9]([C:21]2[CH2:20][CH2:19][CH:18]([CH3:17])[N:22]=2)[C:10]2[C:15]1=[CH:14][CH:13]=[CH:12][CH:11]=2

参加物

4

反応物 3

HCID 226479,9-Dimethyl-9,10-dihydroacridineHCID 24813Phosphorus oxychlorideHCID 660555-Methyl-2-pyrrolidone

生成物 1

HCID 30441679,9-Dimethyl-10-(5-methyl-1-pyrrolin-2-YL)acridan収率 11%

実験手順

Reaction of 9,9-dimethylacridan, 5-methyl-2-pyrrolidinone and phosphorus oxychloride according to the procedure of Example 1 provides the free base 9,9-DIMETHYL-10-(5-METHYL-1-PYRROLIN-2-YL)ACRIDAN as a distillable oil, b.p. 160°-180° C. at 0.15 mm Hg. in 11% yield. Conversion of the free base to the hydrochloride salt affords 9,9-DIMETHYL-10-(5-METHYL-1-PYRROLIN-2-YL)ACRIDAN HYDROCHLORIDE, m.p. 232.5°-234.5° C. (dec.) (corr.), by trituration with hot benzene.

出典と根拠

ORDレコード
ord-93c9315e970242c78422f417f6e050ba
出典データセット
uspto-grants-1977_09
特許番号
US04046891

関連ノート

読み込み中…