Morpholine → 4-Quinazolinamine, 2-(4-morpholinyl)-
反応式
[NH:1]1[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.Cl[C:8]1[N:17]=[C:16]([NH2:18])[C:15]2[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=2)[N:9]=1>O1CCCC1>[O:4]1[CH2:5][CH2:6][N:1]([C:8]2[N:17]=[C:16]([NH2:18])[C:15]3[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=3)[N:9]=2)[CH2:2][CH2:3]1参加物
4
実験手順
A solution of 7 g of morpholine in 25 ml of tetrahydrofuran was added dropwise to a solution of 7.2 g of 2-chloro-4-aminoquinazoline in 75 ml of tetrahydrofuran. After the addition was completed, the mixture was heated at reflux overnight. The reaction mixture was evaporated to dryness and the residue was recrystallized twice from ethanol to give 5 g of 2-morpholino-4-aminoquinazoline; m.p. 216°-219°. The following analytical data were obtained.
後処理
- additionAfter the addition
- temperaturethe mixture was heated
- temperatureat reflux overnight
- customThe reaction mixture was evaporated to dryness
- customthe residue was recrystallized twice from ethanol
出典と根拠
- ORDレコード
- ord-e0c0d851247b411a80bb06751d3d2650
- 出典データセット
- uspto-grants-1977_09
- 特許番号
- US04048312
反応ノート
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