3-[4-(Propan-2-yl)cyclohexyl]propanoic acid → 1,5-Bis[4-(propan-2-yl)cyclohexyl]pentan-3-one

HRID 2071875ノート

反応式

HRID 2071875 の反応式
[CH:1]([CH:4]1[CH2:9][CH2:8][CH:7]([CH2:10][CH2:11][C:12]([OH:14])=O)[CH2:6][CH2:5]1)([CH3:3])[CH3:2]>[Fe]>[CH:1]([CH:4]1[CH2:5][CH2:6][CH:7]([CH2:10][CH2:11][C:12](=[O:14])[CH2:11][CH2:10][CH:7]2[CH2:6][CH2:5][CH:4]([CH:1]([CH3:2])[CH3:3])[CH2:9][CH2:8]2)[CH2:8][CH2:9]1)([CH3:3])[CH3:2]

参加物

3

反応物 1

HCID 213966513-[4-(Propan-2-yl)cyclohexyl]propanoic acid

生成物 1

HCID 213966471,5-Bis[4-(propan-2-yl)cyclohexyl]pentan-3-one

試薬・触媒・溶媒 1

HCID 23925Iron触媒

反応条件

温度
290 °C

実験手順

3-(4-Isopropylcyclohexyl)propionic acid (39.7 g., 0.20 mole) and iron (hydrogen reduced, 6.15 g., 0.11 mole) is heated for 1.5 hours at 195° C. under a nitrogen atmosphere. After that time, the temperature is increased to 290° C. and maintained at that temperature for three hours. The cooled reaction mass is extracted well with ether, filtered through Celite, and the ethereal extracts concentrated under vacuum. The residue is stripped under vacuum to leave the product, 17.3 g. (51%).

後処理

  1. temperaturemaintained at that temperature for three hours
  2. customThe cooled reaction mass
  3. extractionis extracted well with ether
  4. filtrationfiltered through Celite
  5. concentrationthe ethereal extracts concentrated under vacuum
  6. customto leave the product, 17.3 g

出典と根拠

ORDレコード
ord-b0f943ad6dc84a02889d4cc46b1df853
出典データセット
uspto-grants-1977_09
特許番号
US04049417

反応ノート

読み込み中…