Benzoyl chloride → N-{[1-(Dimethylamino)cyclohexyl]methyl}benzamide hydrochloride (1:1)

HRID 2071981ノート

反応式

HRID 2071981 の反応式
[NH2:1][CH2:2][C:3]1([N:9]([CH3:11])[CH3:10])[CH2:8][CH2:7][CH2:6][CH2:5][CH2:4]1.[C:12]([Cl:20])(=[O:19])[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1>N1C=CC=CC=1>[ClH:20].[C:12]([NH:1][CH2:2][C:3]1([N:9]([CH3:11])[CH3:10])[CH2:8][CH2:7][CH2:6][CH2:5][CH2:4]1)(=[O:19])[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1

参加物

4

反応物 2

HCID 7412Benzoyl chlorideHCID 21134031-(Aminomethyl)-N,N-dimethylcyclohexan-1-amine

生成物 1

HCID 21409912N-{[1-(Dimethylamino)cyclohexyl]methyl}benzamide hydrochloride (1:1)

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

実験手順

A mixture of 1-aminomethylcyclohexyldimethylamine (1.5 g), benzoyl chloride (3 ml) and pyridine (10 ml) was allowed to stand at room temperature for 1 hr. The crystalline mass was filtered and recrystallised several times from 95% ethanol to give colourless prisms of 1-benzamidomethylcyclohexyldimethylamine hydrochloride m.p. 245°-6°.

後処理

  1. filtrationThe crystalline mass was filtered
  2. customrecrystallised several times from 95% ethanol

出典と根拠

ORDレコード
ord-a9fd878353ac450f97e391d77f20370c
出典データセット
uspto-grants-1977_09
特許番号
US04049663

反応ノート

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