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Water → 3Formylamino-5-trifluoromethylindazole-1-carboxylic acid dimethylamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Dimethylcarbamoyl Chloride | HCID 6598 | — |
| 反応物 | N-(5-(trifluoromethyl)-1H-indazol-3-yl)formamide | HCID 21409159 | — |
| 溶媒 | Pyridine | HCID 1049 | — |
| 生成物 | 3Formylamino-5-trifluoromethylindazole-1-carboxylic acid dimethylamide | HCID 53697137 | 57% |
反応手順
0.2 mol of 3-formylamino-5-trifluoromethylindazole and 0.05 mol of dimethylcarbamic acid chloride in 20 ml of pyridine are heated for 4 hours to 50° C. After cooling, 150 ml of water are allowed to run in and the reaction product which has crystallized out is isolated by filtration. Recrystallization from ethanol gives 3formylamino-5-trifluoromethylindazole-1-carboxylic acid dimethylamide (melting point: 198°-200° C; 57% of theory).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04051252 |
| 出典データセット | uspto-grants-1977_09 |
| ORD ID | ord-204b62a36e9e4f6490e59b9cf2f417f2 |
| 出典メモ | uspto-grants-1977_09 |