Methyl iodide → 2-Bromo-4-(methylthio)aniline

HRID 2072590ノート

反応式

HRID 2072590 の反応式
[Br:1][C:2]1[CH:8]=[C:7]([S:9][C:10]#N)[CH:6]=[CH:5][C:3]=1[NH2:4].[C-]#N.[Na+].CI>CO>[Br:1][C:2]1[CH:8]=[C:7]([S:9][CH3:10])[CH:6]=[CH:5][C:3]=1[NH2:4]

参加物

5

反応物 3

HCID 6328Methyl iodideHCID 8929Sodium Cyanide2 回HCID 38124212-Bromo-4-thiocyanatoaniline

生成物 1

HCID 146018352-Bromo-4-(methylthio)aniline

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

A solution of 2-bromo-4-thiocyanoaniline (11.5 g., 0.05 mole) and sodium cyanide (1.23 g., 0.025 mole) in methanol (100 ml.) is stirred at room temperature overnight. Sodium cyanide (0.025 mole) is then added and the reaction heated at reflux 2 hours and then cooled (0°-5° C.). Methyl iodide is added and stirring continued. Thin layer chromatography shows one product spot. Product is recovered by extraction with methylene chloride, 8.4 g.

後処理

  1. temperaturethe reaction heated
  2. temperatureat reflux 2 hours
  3. temperaturecooled (0°-5° C.)
  4. customProduct is recovered by extraction with methylene chloride, 8.4 g

出典と根拠

ORDレコード
ord-17ab256e09fa46588c1f0b202f82a60e
出典データセット
uspto-grants-1990_04
特許番号
US04913728

反応ノート

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