Thionyl Chloride → 3-Bromo-4-(2'-methylbutyl)benzoic acid chloride

反応式

S(Cl)([Cl:3])=O.[Br:5][C:6]1[CH:7]=[C:8]([CH:12]=[CH:13][C:14]=1[CH2:15][CH:16]([CH3:19])[CH2:17][CH3:18])[C:9](O)=[O:10]>>[Br:5][C:6]1[CH:7]=[C:8]([CH:12]=[CH:13][C:14]=1[CH2:15][CH:16]([CH3:19])[CH2:17][CH3:18])[C:9]([Cl:3])=[O:10]

参加物

反応物 2

HCID 24386Thionyl Chloride

HCID 198599663-Bromo-4-(2'-methylbutyl)benzoic acid

生成物 1

HCID 538429803-Bromo-4-(2'-methylbutyl)benzoic acid chloride収率 98.1%

実験手順

Thionyl chloride (118 g) was added to the 3-bromo-4-(2'-methylbutyl)benzoic acid (100 g, 0.37 mol) followed by refluxing the mixture for 2 hours and distilling off excess thionyl chloride under reduced pressure to obtain 3-bromo-4-(2'-methylbutyl)benzoic acid chloride (105.1 g).

後処理

temperatureby refluxing the mixture for 2 hours
distillationdistilling off excess thionyl chloride under reduced pressure

出典と根拠

ORDレコード: ord-7960b18b5e314dc7a1ced42d775b266e
出典データセット: uspto-grants-1990_04
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US04913838

反応ノート

読み込み中…

参加物