Water → 1-Triphenylmethyl-4-methyl-5-hydroxymethylimidazole

To a solution of 19 g of 4-hydroxymethyl-5-methylimidazole hydrochloride in 350 ml of dimethylformamide was added 36 ml of triethylamine followed in 10 minutes by the addition of 35 g of trityl chloride. A water bath was used to cool the reaction mixture such that it did not rise above 36° C. After stirring at room temperature for 4 hours, the mixture was poured into 1 liter of water and ice. The resulting precipitate was filtered and washed with acetone (2×250 ml) to give 22 g of product.

1. customA water bath was used
2. temperatureto cool the reaction mixture such that it
3. customdid not rise above 36° C
4. filtrationThe resulting precipitate was filtered
5. washwashed with acetone (2×250 ml)

ORDレコード

ord-4ae091fd0a714b769b55cad1b73dfb59

出典データセット

uspto-grants-1990_04

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US04914207