Acetic Anhydride → 2-(2,4-Dichloro-benzoyl)-3-methoxyacrylonitrile
反応式
[Cl:1][C:2]1[CH:12]=[C:11]([Cl:13])[CH:10]=[CH:9][C:3]=1[C:4]([CH2:6][C:7]#[N:8])=[O:5].[C:14]([O:17][C:18](=O)C)(=O)C>>[Cl:1][C:2]1[CH:12]=[C:11]([Cl:13])[CH:10]=[CH:9][C:3]=1[C:4]([C:6](=[CH:14][O:17][CH3:18])[C:7]#[N:8])=[O:5]参加物
3
反応条件
- 温度
- 150 °C
実験手順
A mixture of 8.8 g of 2,4-dichloro-benzoylacetonitrile, 69.2 g of methyl o-formate and 10.5 g of acetic anhydride is refluxed at a bath temperature of 150° C. for 3 hours. The volatile constituents are then distilled off in vacuo and finally under a fine vacuum at a bath temperature of 120° C. 11 g of 2-(2,4-dichloro-benzoyl)-3-methoxy-acrylonitrile are obtained as a viscous oil.
後処理
- distillationThe volatile constituents are then distilled off in vacuo and finally under a fine vacuum at a bath temperature of 120° C
出典と根拠
- ORDレコード
- ord-391df9ca579547fd8fe272604eefc0dd
- 出典データセット
- uspto-grants-1990_04
- 特許番号
- US04914228
反応ノート
読み込み中…