Ethanol → HCID 19858041、化合物

HRID 2073396ノート

反応式

HRID 2073396 の反応式
[CH3:1][C:2]1([CH3:24])[C:6](=[O:7])[O:5][C:4]2[CH:8]=[CH:9][C:10]3[C:15]([C:3]1=2)=[CH:14][C:13]([CH2:16][N:17]1[CH:21]=[N:20][CH:19]=[N:18]1)=[C:12]([C:22]#[N:23])[CH:11]=3.C(O)C.[BH4-].[Na+]>O>[OH:7][CH:6]1[O:5][C:4]2[CH:8]=[CH:9][C:10]3[C:15]([C:3]=2[C:2]1([CH3:24])[CH3:1])=[CH:14][C:13]([CH2:16][N:17]1[CH:21]=[N:20][CH:19]=[N:18]1)=[C:12]([C:22]#[N:23])[CH:11]=3

参加物

5

反応物 3

HCID 702EthanolHCID 4311764Sodium borohydrideHCID 54516723HCID 54516723、化合物

生成物 1

HCID 19858041HCID 19858041、化合物

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A mixture of 1,2-dihydro-1,1-dimethyl-2-oxo-8-(1H-1,2,4-triazol-1-ylmethyl)naphtho[2,1-b]furan-7-carbonitrile (0.07 g), ethanol (2 ml) and sodium borohydride (0.05 g) was stirred at room temperature for 18 h. Water (10 ml) was added, and the mixture was extracted with chloroform, and the extract was dried and evaporated to dryness under reduced pressure. The residue was recrystallised from ethyl acetate to give 1,2-dihydro-2-hydroxy-1,1-dimethyl-8-(1H-1,2,4-triazol-1-ylmethyl)naphtho[2,1-b]furan-7-carbonitrile, m.p. 219°-222°.

後処理

  1. extractionthe mixture was extracted with chloroform
  2. customthe extract was dried
  3. customevaporated to dryness under reduced pressure
  4. customThe residue was recrystallised from ethyl acetate

出典と根拠

ORDレコード
ord-a6e6917a777848b0ad0154da5d361eb1
出典データセット
uspto-grants-1990_04
特許番号
US04916148

反応ノート

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