Hydrochloric Acid → HCID 19858084、化合物

反応式

[OH:1][CH:2]([C:7]1[CH:19]=[C:18]2[C:10]([CH:11]=[CH:12][C:13]3[O:14][C:15](=[O:22])[C:16]([CH3:21])([CH3:20])[C:17]=32)=[CH:9][CH:8]=1)[C:3]([F:6])([F:5])[F:4].N1C=CC=CC=1.[S:29](Cl)([C:32]1[CH:38]=[CH:37][C:35]([CH3:36])=[CH:34][CH:33]=1)(=[O:31])=[O:30].Cl>O>[CH3:21][C:16]1([CH3:20])[C:15](=[O:22])[O:14][C:13]2[CH:12]=[CH:11][C:10]3[C:18]([C:17]1=2)=[CH:19][C:7]([CH:2]([O:1][S:29]([C:32]1[CH:38]=[CH:37][C:35]([CH3:36])=[CH:34][CH:33]=1)(=[O:31])=[O:30])[C:3]([F:4])([F:6])[F:5])=[CH:8][CH:9]=3

参加物

実験手順

A mixture of 8-(1-hydroxy-2,2,2-trifluoroethyl)-1,1-dimethyl-2(1H)-naphtho[2,1-b]furanone (0.04 g), pyridine (0.5 ml) and tosyl chloride (0.04 g) was stirred at room temperature for 18 h and then heated at 50° for 6 h. The mixture was cooled to room temperature, treated with water (10 ml) and the mixture was stirred at room temperature for 5 minutes and acidified with 2N aqueous hydrochloric acid. The mixture was extracted with ethyl acetate and the extract was dried and evaporated to dryness under reduced pressure to give the required starting material, 1,1-dimethyl-8-(2,2,2-trifluoro-1-tosyloxyethyl)-2(1H)-naphtho[2,1-b]furanone, which was used without further purification. ##STR3##