Hydrochloric Acid → ethyl N-(piperidin-4-yl)carbamate
反応式
C([N:8]1[CH2:13][CH2:12][CH:11]([NH:14][C:15]([O:17][CH2:18][CH3:19])=[O:16])[CH2:10][CH2:9]1)C1C=CC=CC=1.Cl>CO.[Pd]>[CH2:18]([O:17][C:15]([NH:14][CH:11]1[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]1)=[O:16])[CH3:19]参加物
5
実験手順
16 g (61 mmol) of 1-benzyl-4-ethoxycarbonylaminopiperidine were hydrogenated in 240 ml of methanol and 80 ml of 10% strength methanolic hydrochloric acid on 4 g of palladium-on-charcoal (10%) at 45° C. in a shaking vessel for 90 minutes. The catalyst was filtered off with suction, the solvent was evaporated off, the residue was dissolved in 400 ml of ethanol and the solution was neutralized with ethanolic NaOH. The NaCl which had precipitated out was filtered off and the filtrate was concentrated.
後処理
- filtrationThe catalyst was filtered off with suction
- customthe solvent was evaporated off
- dissolutionthe residue was dissolved in 400 ml of ethanol
- customThe NaCl which had precipitated out
- filtrationwas filtered off
- concentrationthe filtrate was concentrated
出典と根拠
- ORDレコード
- ord-d4c3d812ba444ead846192a84d43bba4
- 出典データセット
- uspto-grants-1990_04
- 特許番号
- US04918073
反応ノート
読み込み中…