HCID 85585332、化合物 → HCID 11551221、化合物

HRID 2073515ノート

反応式

HRID 2073515 の反応式
[N:1]([CH2:4][CH2:5][O:6][C:7]1[CH:20]=[CH:19][C:10]([CH2:11][CH:12]2[S:16][C:15](=[O:17])[NH:14][C:13]2=[O:18])=[CH:9][CH:8]=1)=[N+]=[N-]>CO.[Pd]>[NH2:1][CH2:4][CH2:5][O:6][C:7]1[CH:20]=[CH:19][C:10]([CH2:11][CH:12]2[S:16][C:15](=[O:17])[NH:14][C:13]2=[O:18])=[CH:9][CH:8]=1

参加物

4

反応物 1

HCID 85585332HCID 85585332、化合物

生成物 1

HCID 11551221HCID 11551221、化合物

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

A solution of 5-[4-(2-Azidoethoxy)Benzyl]2,4-Thiazolidinedione (5 g) in Methanol (100 ml) was reduced under hydrogen at ambient temperature and pressure in the presence of 10% palladium on charcoal (5 g) for 18 hours. The mixture was filtered through diatomaceous earth and the filter pad was washed exhaustively with Methanol. The combined filtrates was evaporated to dryness under reduced pressure and the title compound (m.p. 175°-6° C.) was obtained as a dihydrate following crystallisation from methanol.

後処理

  1. customwas reduced under hydrogen at ambient temperature
  2. filtrationThe mixture was filtered through diatomaceous earth
  3. washthe filter pad was washed exhaustively with Methanol
  4. customThe combined filtrates was evaporated to dryness under reduced pressure

出典と根拠

ORDレコード
ord-f397d873a105467088b3b77f059efa28
出典データセット
uspto-grants-1990_04
特許番号
US04918091

反応ノート

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