6-Fluoronaphthalene-1-carboxylic acid → HCID 14987239、化合物
反応式
[CH3:1][Li].[F:3][C:4]1[CH:5]=[C:6]2[C:11](=[CH:12][CH:13]=1)[C:10]([C:14]([OH:16])=O)=[CH:9][CH:8]=[CH:7]2>C1COCC1>[F:3][C:4]1[CH:5]=[C:6]2[C:11](=[CH:12][CH:13]=1)[C:10]([C:14](=[O:16])[CH3:1])=[CH:9][CH:8]=[CH:7]2参加物
4
実験手順
Methyl lithium (1.59M solution in ether; 4.2 ml) was added dropwise to a stirred solution of 6-fluoro-1-naphthalene carboxylic acid (640 mg) in dry THF (10 ml) at -78° under nitrogen. The solution was stirred at -78° for 2 h and was slowly allowed to warm to -15°. The solution was quenched with saturated aqueous ammonium chloride (1 ml) and partitioned between 2N sodium hydroxide (25 ml) and ethyl acetate (25 ml). The organic phase was dried and evaporated to give the title compound (404 mg) as an oil, t.l.c. (System B, 1:6) Rf 0.2.
後処理
- temperatureto warm to -15°
- customThe solution was quenched with saturated aqueous ammonium chloride (1 ml)
- custompartitioned between 2N sodium hydroxide (25 ml) and ethyl acetate (25 ml)
- customThe organic phase was dried
- customevaporated
出典と根拠
- ORDレコード
- ord-34b7d80f4ebb410c944c0c954ab47f72
- 出典データセット
- uspto-grants-1990_04
- 特許番号
- US04918080
反応ノート
読み込み中…