Thionyl Chloride → 2,4-Dibenzyloxyphenylacetyl chloride

HRID 2073567ノート

反応式

HRID 2073567 の反応式
[CH2:1]([O:8][C:9]1[CH:14]=[C:13]([O:15][CH2:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[CH:12]=[CH:11][C:10]=1[CH2:23][C:24]([OH:26])=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.S(Cl)([Cl:29])=O>C1C=CC=CC=1>[CH2:1]([O:8][C:9]1[CH:14]=[C:13]([O:15][CH2:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[CH:12]=[CH:11][C:10]=1[CH2:23][C:24]([Cl:29])=[O:26])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

4

反応物 2

HCID 24386Thionyl ChlorideHCID 50283782-[2,4-Bis(benzyloxy)phenyl]acetic Acid

生成物 1

HCID 138730072,4-Dibenzyloxyphenylacetyl chloride

試薬・触媒・溶媒 1

HCID 241Benzene溶媒

実験手順

2,4-Dibenzyloxyphenylacetic acid [IX] (1.4 g) was dissolved in anhydrous benzene (30 ml) and then thereto was added thionyl chloride (5 g) and the mixture was left to stand at room temperature (20° C.) for 20 minutes. The reaction mixture was concentrated to dryness under reduced pressure to obtain crude 2,4-dibenzyloxyphenylacetyl chloride [X]. This was used for the subsequent reaction without purification.

後処理

  1. waitthe mixture was left
  2. customto stand at room temperature
  3. custom(20° C.)
  4. customfor 20 minutes
  5. concentrationThe reaction mixture was concentrated to dryness under reduced pressure

出典と根拠

ORDレコード
ord-6a910550abf546b2aa0050721bd44d49
出典データセット
uspto-grants-1990_04
特許番号
US04918107

反応ノート

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