Thionyl Chloride → 9-Acridinecarbonyl chloride
反応式
O.[CH:2]1[C:15]2[C:6](=[N:7][C:8]3[C:13]([C:14]=2[C:16]([OH:18])=O)=[CH:12][CH:11]=[CH:10][CH:9]=3)[CH:5]=[CH:4][CH:3]=1.S(Cl)([Cl:21])=O>>[CH:2]1[C:15]2[C:6](=[N:7][C:8]3[C:13]([C:14]=2[C:16]([Cl:21])=[O:18])=[CH:12][CH:11]=[CH:10][CH:9]=3)[CH:5]=[CH:4][CH:3]=1参加物
3
実験手順
A mixture of 9-acridinecarboxylic acid hydrate (7.3 g, 30 mmole), and thionyl chloride (50 ml, 0.685 mole) was heated at reflux in a round bottom flask equipped with a reflux condenser, a drying tube, and a stirring bar. The reaction mixture was heated further for one hour after the dissolution occurred, then cooled and evaporated to remove any excess thionyl chloride. The residue was directly utilized in the subsequent reaction without further purification.
後処理
- temperaturewas heated
- temperatureat reflux in a round bottom flask
- customequipped with a reflux condenser, a drying tube, and a stirring bar
- temperatureThe reaction mixture was heated further for one hour
- dissolutionafter the dissolution
- temperaturecooled
- customevaporated
- customto remove any excess thionyl chloride
- customThe residue was directly utilized in the subsequent reaction without further purification
出典と根拠
- ORDレコード
- ord-9f1ea78a5ad44d4abe73d4b689239890
- 出典データセット
- uspto-grants-1990_04
- 特許番号
- US04918192
反応ノート
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