Methyl iodide → HCID 15075811、化合物

反応式

[F:1][C:2]1[CH:7]=[C:6]([F:8])[C:5]([F:9])=[CH:4][C:3]=1[C:10]1[O:11][CH2:12][C:13]([CH3:16])([CH3:15])[N:14]=1.[CH:17]([N-]C(C)C)(C)C.[Li+].CI>>[F:1][C:2]1[C:7]([CH3:17])=[C:6]([F:8])[C:5]([F:9])=[CH:4][C:3]=1[C:10]1[O:11][CH2:12][C:13]([CH3:16])([CH3:15])[N:14]=1

参加物

反応物 3

HCID 6328Methyl iodide

HCID 2724682Lithium diisopropylamide

HCID 110097342-(2,4,5-Trifluorophenyl)-4,5-dihydro-4,4-dimethyloxazole

生成物 1

HCID 15075811HCID 15075811、化合物

実験手順

The 2-(2,4,5-trifluorophenyl)-4,4-dimethyl-2-oxazoline was also treated with lithium diisopropylamide followed by methyl iodide to give 2-(2,4,5-trifluoro-3-methylphenyl)-4,4-dimethyl-2-oxazoline. This intermediate was, in turn, treated with lithium diisopropylamide, then with methyl iodide, to give 2-(2,4,5-trifluoro-3,6-dimethylphenyl)-4,4-dimethyl-2-oxazoline. Hydrolysis of the oxazoline gave 2,4,5-trifluoro-3,6-dimethylbenzoic acid, which was elaborated into 1-cyclopropyl-6,7-difluoro-1,4-dihydro-5,8-dimethyl-4-oxo-3-quinolinecarboxylic acid in the usual manner.