Hydrogen Bromide → HCID 14370125、化合物
反応式
[C:1]([C:4]1[CH:5]=[C:6]([C:12]#[N:13])[C:7]([NH2:11])=[N:8][C:9]=1[CH3:10])(=[O:3])[CH3:2].[BrH:14].BrBr>C(O)(=O)C>[NH2:11][C:7]1[C:6]([C:12]#[N:13])=[CH:5][C:4]([C:1](=[O:3])[CH2:2][Br:14])=[C:9]([CH3:10])[N:8]=1参加物
5
反応条件
- 温度
- 45 °C
実験手順
2.7 g (15.4 mmol) of 5-acetyl-2-amino-3-cyano-6-methyl-pyridine are suspended in 110 ml of glacial acetic acid, and 1.9 ml (16.2 mmol) of 48% strength HBr are added. Then 5.2 g (32.4 mmol) of bromine are added, and the mixture is stirred at 45° C. for five hours. After cooling, the mixture is filtered with suction and the filter cake is stirred with NaHCO3 solution, filtered with suction and dried. Recrystallization from ethanol is used for purification.
後処理
- temperatureAfter cooling
- filtrationthe mixture is filtered with suction
- stirringthe filter cake is stirred with NaHCO3 solution
- filtrationfiltered with suction
- customdried
- customRecrystallization from ethanol
- customis used for purification
出典と根拠
- ORDレコード
- ord-b9bb4e605f074ba1aab4a5319bc4f9bc
- 出典データセット
- uspto-grants-1990_04
- 特許番号
- US04920136
反応ノート
読み込み中…