Sodium borohydride → Ethyl 2-(3-(2-(3-(2-quinolinylmethyloxy)phenyl)-2-hydroxyethyl)phenoxy)acetate

HRID 2073907ノート

反応式

HRID 2073907 の反応式
[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[CH2:11][O:12][C:13]1[CH:14]=[C:15]([C:19](=[O:34])[CH2:20][C:21]2[CH:22]=[C:23]([CH:31]=[CH:32][CH:33]=2)[O:24][CH2:25][C:26]([O:28][CH2:29][CH3:30])=[O:27])[CH:16]=[CH:17][CH:18]=1.[BH4-].[Na+]>CCO.O>[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[CH2:11][O:12][C:13]1[CH:14]=[C:15]([CH:19]([OH:34])[CH2:20][C:21]2[CH:22]=[C:23]([CH:31]=[CH:32][CH:33]=2)[O:24][CH2:25][C:26]([O:28][CH2:29][CH3:30])=[O:27])[CH:16]=[CH:17][CH:18]=1

参加物

5

反応物 2

HCID 4311764Sodium borohydrideHCID 14774137Ethyl 2-(3-(2-(3-(2-quinolinylmethyloxy)phenyl)-2-oxoethyl)phenoxy)acetate

生成物 1

HCID 14774138Ethyl 2-(3-(2-(3-(2-quinolinylmethyloxy)phenyl)-2-hydroxyethyl)phenoxy)acetate

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 962Water溶媒

実験手順

The product obtained from Step B (5 mmol) in 50 mL of EtOH is treated with (2 mmol) of NaBH4 at room temperature. After 30 min, the reaction mixture is diluted with water and extracted with EtOAc. The organic solution is dried and evaporated and purified by dry column chromatography to give ethyl 2-(3-(2-(3-(2-quinolinylmethyloxy)phenyl)-2-hydroxyethyl)phenoxy)acetate.

後処理

  1. extractionextracted with EtOAc
  2. customThe organic solution is dried
  3. customevaporated
  4. custompurified
  5. customby dry column chromatography

出典と根拠

ORDレコード
ord-8300174cf1b942c1856094dc8b999309
出典データセット
uspto-grants-1990_04
特許番号
US04920131

反応ノート

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