Methyl iodide → Methyl 3-allyl-2-methoxy-4-amino-5-chlorobenzoate

反応式

[C:1](=O)([O-])[O-].[K+].[K+].CI.[CH2:9]([C:12]1[C:13]([OH:24])=[C:14]([CH:19]=[C:20]([Cl:23])[C:21]=1[NH2:22])[C:15]([O:17][CH3:18])=[O:16])[CH:10]=[CH2:11]>CC(C)=O>[CH2:9]([C:12]1[C:13]([O:24][CH3:1])=[C:14]([CH:19]=[C:20]([Cl:23])[C:21]=1[NH2:22])[C:15]([O:17][CH3:18])=[O:16])[CH:10]=[CH2:11]

参加物

実験手順

A mixture of potassium carbonate (19 g), methyl iodide (8 g) and the phenolic compound of step 2 above (3.4 g) in acetone (100 ml) is stirred under reflux for about 6.4 hours. The mixture is partitioned between CH2Cl2 and H2O, and the organic layer is separated and washed with 10% aqueous HCl, dried (MgSO4) and evaporated affording an oil which chromatographed on silica gel affording the desired product which is used in the next step.