Sodium Hydroxide → 6-Carboxy-8-chloro-5-methoxy-1,2,3,4-tetrahydroquinoline

HRID 2074009ノート

反応式

HRID 2074009 の反応式
[C:1]([C:5]1[C:6]([O:16][CH3:17])=[C:7]2[C:12](=[C:13]([Cl:15])[CH:14]=1)[NH:11][CH2:10][CH2:9][CH2:8]2)([O:3]C)=[O:2].[OH-].[Na+]>CO>[C:1]([C:5]1[C:6]([O:16][CH3:17])=[C:7]2[C:12](=[C:13]([Cl:15])[CH:14]=1)[NH:11][CH2:10][CH2:9][CH2:8]2)([OH:3])=[O:2]

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 148832316-Carbomethoxy-8-chloro-5-methoxy-1,2,3,4-tetrahydroquinoline

生成物 1

HCID 148832326-Carboxy-8-chloro-5-methoxy-1,2,3,4-tetrahydroquinoline

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

反応条件

温度
0 °C

実験手順

A mixture of the compound of step 5 above (1.1 g), 10% aqueous NaOH (20 ml) and MeOH (40 ml) is stirred under reflux for 30 minutes. The MeOH is evaporated and the aqueous residue partitioned with CHCl3. The mixture is stirred vigorously, cooled to 0° C. and treated with 10% HCl (28 mls). The aqueous layer is separated and the organic layer is dried and evaporated. The residue is crystallized from ether affording the desired product, M.P. 129°-132° C.

後処理

  1. temperatureunder reflux for 30 minutes
  2. customThe MeOH is evaporated
  3. customthe aqueous residue partitioned with CHCl3
  4. stirringThe mixture is stirred vigorously
  5. additiontreated with 10% HCl (28 mls)
  6. customThe aqueous layer is separated
  7. customthe organic layer is dried
  8. customevaporated
  9. customThe residue is crystallized from ether affording the desired product, M.P. 129°-132° C.

出典と根拠

ORDレコード
ord-3c2d61108b674c17b1bac65668b3200a
出典データセット
uspto-grants-1990_04
特許番号
US04920219

反応ノート

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