Benzofuran, 5-bromo- → 5-Isobutylbenzofuran

温度

100 °C

5-bromobenzofuran (500 mg, 2.56 mmol) was dissolved in THF solution of isobutylzinc(II) bromide (0.5M, 15 mL, 7.40 mmol) in a microwave reaction tube. Pd(PtBu3)2 (65 mg, 0.128 mmol, 0.05 eqv.) was added to this solution. The mixture was purged with N2 gas for 3-5 min and heated at 100° C. for 30 min under microwave irradiation. Upon completion of the reaction, the reaction mixture was diluted with ethyl acetate, washed with 1N HCl aqueous solution, brine, filtered through Celite. The filtrate was dried over Na2SO4 and concentrated. The residue was purified by silica gel column chromatography (ISCO system, 5% EtOAc in hexanes) to give 0.331 g desired product (74% yield): 1H NMR (400 MHz, CDCl3) δ 7.59 (s, 1H), 7.35 (d, 1H), 7.07 (d, 1H), 6.70 (s, 1H), 2.59 (d, 2H), 1.9 (m, 1H), 0.9 (d, 6H).

1. customThe mixture was purged with N2 gas for 3-5 min
2. customUpon completion of the reaction
3. washwashed with 1N HCl aqueous solution, brine
4. filtrationfiltered through Celite
5. dry with materialThe filtrate was dried over Na2SO4
6. concentrationconcentrated
7. customThe residue was purified by silica gel column chromatography (ISCO system, 5% EtOAc in hexanes)

ORDレコード

ord-9f61e3591a404270ab4b0b3749aa2342

出典データセット

uspto-grants-2011_04

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US07919519B2