Water → 2-Amino-4-phenoxyphenol

HRID 2075260ノート

反応式

HRID 2075260 の反応式
O.[N+:2]([C:5]1[CH:10]=[C:9]([O:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH:8]=[CH:7][C:6]=1[OH:18])([O-])=O>[Pd].CO>[NH2:2][C:5]1[CH:10]=[C:9]([O:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH:8]=[CH:7][C:6]=1[OH:18]

参加物

5

反応物 2

HCID 962WaterHCID 107758492-Nitro-4-phenoxyphenol

生成物 1

HCID 106795632-Amino-4-phenoxyphenol

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

10% Palladium on carbon, 50% water wet (1.43 g, 1.34 mmol) and 2-nitro-4-phenoxyphenol (3.10 g, 13.4 mmol) were combined under nitrogen and 30 mL MeOH was added. The mixture was exposed to H2 from a balloon and was stirred rapidly overnight. In the morning the reaction was flushed with nitrogen and filtered and concentrated in vacuo to give 2-amino-4-phenoxyphenol as a light brown solid. MS (ESI) m/z: Calculated: 201.1; Observed: 202.1 (M++1).

後処理

  1. customIn the morning the reaction was flushed with nitrogen
  2. filtrationfiltered
  3. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-4810189d3e064b349a330cc3695d81b7
出典データセット
uspto-grants-2011_04
特許番号
US07919519B2

反応ノート

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