Methyl iodide → HCID 178483384、化合物

HRID 2075428ノート

反応式

HRID 2075428 の反応式
[CH3:1][N:2]([CH2:4][C:5]1[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[NH:7][N:6]=1)[CH3:3].[CH3:14][I:15]>C(OCC)(=O)C>[I-:15].[NH:7]1[C:8]2[C:13](=[CH:12][CH:11]=[CH:10][CH:9]=2)[C:5]([CH2:4][N+:2]([CH3:14])([CH3:1])[CH3:3])=[N:6]1

参加物

4

反応物 2

HCID 6328Methyl iodideHCID 178483331(1H-Indazol-3-yl)-N,N-dimethylmethanamine

生成物 1

HCID 178483384HCID 178483384、化合物収率 97.2%

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒

実験手順

3-Dimethylaminomethyl-1H-indazole (25.6 g, 146 mmol) obtained in Step 2 was dissolved in ethyl acetate (350 mL), and the solution was added with methyl iodide (33.3 mL, 535 mmol), followed by stirring at room temperature overnight. The resulting precipitates were collected by filtration to obtain (1H-indazol-3-ylmethyl)trimethylammonium iodide (45.0 g, 97%).

後処理

  1. customThe resulting precipitates
  2. filtrationwere collected by filtration

出典と根拠

ORDレコード
ord-5bab7faaed084fa6b6a4e1182aafa751
出典データセット
uspto-grants-2011_04
特許番号
US07919517B2

反応ノート

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