化工社化工社 化学情報印刷レポート · 研究参考用
Morpholine → 4-(4-Nitropyridin-2-yl)morpholine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Morpholine | HCID 8083 | — |
| 反応物 | 4-Nitropyridine | HCID 70734 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | 4-(4-Nitropyridin-2-yl)morpholine | HCID 57418546 | 56.5% |
反応手順
To a solution of 2-chloro, 4-nitropyridine (0.2 g, 1.27 mmol) in THF (3 mL) was added morpholine (328 mg, 38.1 mmol). The reaction was heated to 80 C and stirred overnight. The solvent was evaporated and the residue purified by column chromatography (2/1 Hex/EtOAc) to yield 150 mg of the target compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07919617B2 |
| 出典データセット | uspto-grants-2011_04 |
| ORD ID | ord-36c9a65afa0142cd9b3d504a40cb6217 |
| 出典メモ | uspto-grants-2011_04 |