反应详情

To a solution of 2-chloro, 4-nitropyridine (0.2 g, 1.27 mmol) in THF (3 mL) was added morpholine (328 mg, 38.1 mmol). The reaction was heated to 80 C and stirred overnight. The solvent was evaporated and the residue purified by column chromatography (2/1 Hex/EtOAc) to yield 150 mg of the target compound.

1. temperatureThe reaction was heated to 80 C
2. customThe solvent was evaporated
3. customthe residue purified by column chromatography (2/1 Hex/EtOAc)