Hydroxyamine hydrochloride → HCID 72327488、化合物

HRID 2075944ノート

反応式

HRID 2075944 の反応式
[CH2:1]([O:8][C:9]1[C:16]([O:17][CH3:18])=[CH:15][C:12]([CH:13]=O)=[C:11]([I:19])[CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl.[NH2:21][OH:22].C([O-])(=O)C.[Na+]>C(O)C>[CH2:1]([O:8][C:9]1[C:16]([O:17][CH3:18])=[CH:15][C:12]([CH:13]=[N:21][OH:22])=[C:11]([I:19])[CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

5

反応物 3

HCID 443297Hydroxyamine hydrochlorideHCID 517045Sodium AcetateHCID 127730874-Benzyloxy-2-iodo-5-methoxybenzaldehyde

生成物 1

HCID 72327488HCID 72327488、化合物収率 100.8%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

反応条件

温度
70 °C

実験手順

A mixture of 4-benzyloxy-2-iodo-5-methoxybenzaldehyde (Reference example 1-1) (12.2 g), hydroxylamine hydrochloride (2.54 g), sodium acetate (6 g) and ethanol (170 mL) was stirred at 70° C. for 1.5 hours. The mixture was concentrated under reduced pressure. Water was added to the residue, and the mixture was stirred at room temperature for 30 minutes. The solid was collected by filtration to give the title compound (12.8 g).

後処理

  1. concentrationThe mixture was concentrated under reduced pressure
  2. additionWater was added to the residue
  3. stirringthe mixture was stirred at room temperature for 30 minutes
  4. filtrationThe solid was collected by filtration

出典と根拠

ORDレコード
ord-f2f2c3d529ca45829e407764367a9513
出典データセット
uspto-grants-2011_04
特許番号
US07923462B2

反応ノート

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