Bromine → 2-Bromo-6-(2-methoxy-phenyl)-cyclohexanone

HRID 2075986ノート

反応式

HRID 2075986 の反応式
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[CH:9]1[CH2:14][CH2:13][CH2:12][CH2:11][C:10]1=[O:15].[Br:16]Br>C(Cl)(Cl)Cl>[Br:16][CH:11]1[CH2:12][CH2:13][CH2:14][CH:9]([C:4]2[CH:5]=[CH:6][CH:7]=[CH:8][C:3]=2[O:2][CH3:1])[C:10]1=[O:15]

参加物

4

反応物 2

HCID 24408BromineHCID 282984Cyclohexanone,2-(2-methoxyphenyl)-

生成物 1

HCID 670958932-Bromo-6-(2-methoxy-phenyl)-cyclohexanone収率 64.1%

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒2 回

実験手順

2-(2-Methoxy-phenyl)-cyclohexanone (51 mg, 0.27 mmol) was dissolved in chloroform (1 mL). To this solution bromine (45.4 mg, 0.28 mmol) in chloroform (0.5 mL) was added drop wise at room temperature. The reaction was stirred for 3 hours at room temperature and the solvent was removed under reduced pressure to yield the crude title compound (49 mg) which was used directly in the next step without further purification.

後処理

  1. customthe solvent was removed under reduced pressure

出典と根拠

ORDレコード
ord-dfb7577146224dbeacf490966ca91a7a
出典データセット
uspto-grants-2011_04
特許番号
US07923450B2

反応ノート

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