Bromine → 6-Bromo-2-(3-methoxy-phenyl)-2-propyl-cyclohexanone

HRID 2075988ノート

反応式

HRID 2075988 の反応式
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:9]2([CH2:16][CH2:17][CH3:18])[CH2:14][CH2:13][CH2:12][CH2:11][C:10]2=[O:15])[CH:6]=[CH:7][CH:8]=1.[Br:19]Br>C(Cl)(Cl)Cl>[Br:19][CH:11]1[C:10](=[O:15])[C:9]([C:5]2[CH:6]=[CH:7][CH:8]=[C:3]([O:2][CH3:1])[CH:4]=2)([CH2:16][CH2:17][CH3:18])[CH2:14][CH2:13][CH2:12]1

参加物

4

反応物 2

HCID 24408BromineHCID 670959582-(3-Methoxy-phenyl)-2-propyl-cyclohexanone

生成物 1

HCID 670961976-Bromo-2-(3-methoxy-phenyl)-2-propyl-cyclohexanone収率 94.5%

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒2 回

反応条件

温度
50 °C

実験手順

2-(3-Methoxy-phenyl)-2-propyl-cyclohexanone (100 mg, 0.41 mmol) was dissolved in chloroform (1 mL). To this solution bromine (68.1 mg, 0.43 mmol) in chloroform (0.5 mL) was added drop wise at −11° C. The reaction was stirred at 5° C. for 1½ hours, at room temperature for 1 hour and at 50° C. for 1 hour. The solvent was removed under reduced pressure to yield the crude title compound (126 mg) which was used directly in the next step without further purification.

後処理

  1. customThe solvent was removed under reduced pressure

出典と根拠

ORDレコード
ord-e2df7ad0133d4a8c94f57f5d9198a2f4
出典データセット
uspto-grants-2011_04
特許番号
US07923450B2

反応ノート

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