Bromine → 6-Bromo-2-(4-trifluoromethoxy-phenyl)-cyclohexanone

HRID 2075992ノート

反応式

HRID 2075992 の反応式
[F:1][C:2]([F:18])([F:17])[O:3][C:4]1[CH:9]=[CH:8][C:7]([CH:10]2[CH2:15][CH2:14][CH2:13][CH2:12][C:11]2=[O:16])=[CH:6][CH:5]=1.[Br:19]Br>C(Cl)(Cl)Cl>[Br:19][CH:12]1[C:11](=[O:16])[CH:10]([C:7]2[CH:6]=[CH:5][C:4]([O:3][C:2]([F:17])([F:18])[F:1])=[CH:9][CH:8]=2)[CH2:15][CH2:14][CH2:13]1

参加物

4

反応物 2

HCID 24408BromineHCID 210825892-(4-Trifluoromethoxyl-phenyl)-cyclohexanone

生成物 1

HCID 670961346-Bromo-2-(4-trifluoromethoxy-phenyl)-cyclohexanone収率 91.8%

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒2 回

実験手順

2-(4-Trifluoromethoxyl-phenyl)-cyclohexanone (53 mg, 0.21 mmol) was dissolved in chloroform (1 mL). To this solution bromine (34.4 mg, 0.22 mmol) in chloroform (0.5 mL) was added drop wise at room temperature. The reaction was stirred for 1½ hours at room temperature. The solvent was removed under reduced pressure to yield the crude title compound (65 mg) which was used directly in the next step without further purification.

後処理

  1. customThe solvent was removed under reduced pressure

出典と根拠

ORDレコード
ord-9d1370a153124d72bfb1f0b3e567ff88
出典データセット
uspto-grants-2011_04
特許番号
US07923450B2

反応ノート

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