Bromine → 6-Bromo-2-(2-chloro-phenyl)-cyclohexanone

HRID 2076000ノート

反応式

HRID 2076000 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH:8]1[CH2:13][CH2:12][CH2:11][CH2:10][C:9]1=[O:14].[Br:15]Br>C(Cl)(Cl)Cl>[Br:15][CH:10]1[C:9](=[O:14])[CH:8]([C:3]2[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=2[Cl:1])[CH2:13][CH2:12][CH2:11]1

参加物

4

反応物 2

HCID 24408BromineHCID 43741102-(2-Chlorophenyl)cyclohexan-1-one

生成物 1

HCID 670959316-Bromo-2-(2-chloro-phenyl)-cyclohexanone収率 112.7%

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒2 回

実験手順

2-(2-Chloro-phenyl)-cyclohexanone (51 mg, 0.25 mmol) was dissolved in chloroform (1 mL). To this solution bromine (42.3 mg, 0.27 mmol) in chloroform (0.5 mL) was added drop wise at room temperature. The reaction was stirred for 1½ hours at room temperature. The solvent was removed under reduced pressure to yield the crude title compound (81 mg) which was used directly in the next step without further purification.

後処理

  1. customThe solvent was removed under reduced pressure

出典と根拠

ORDレコード
ord-3692381de02345ea9f4071bb1c056bd5
出典データセット
uspto-grants-2011_04
特許番号
US07923450B2

反応ノート

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