Sodium Hydroxide → 7,8-dihydrocyclopenta[e]indazol-6(3H)-one
反応式
C([N:4]1[C:12]2[CH:11]=[CH:10][C:9]3[C:13](=[O:16])[CH2:14][CH2:15][C:8]=3[C:7]=2[CH:6]=[N:5]1)(=O)C.[OH-].[Na+]>CO>[CH:6]1[C:7]2[C:8]3[CH2:15][CH2:14][C:13](=[O:16])[C:9]=3[CH:10]=[CH:11][C:12]=2[NH:4][N:5]=1参加物
4
実験手順
To a suspension of 3-acetyl-7,8-dihydrocyclopenta[e]indazol-6(3H) -one (9.19 g, 42.9 mmol) in methanol (250 mL) was added 1N aqueous sodium hydroxide (55.6 mL, 55.6 mmol). The resulting brown solution was stirred at room temperature for 1 hour. The methanol was evaporated under vacuum and the residue was diluted with water (250 mL) and adjusted to pH 4 with 6N aqueous HCl. The resulting precipitate was isolated by filtration, washed thoroughly with water and dried under vacuum to give 7,8-dihydrocyclopenta[e]indazol-6(3H)-one as a yellow solid.
後処理
- customThe methanol was evaporated under vacuum
- additionthe residue was diluted with water (250 mL)
- customThe resulting precipitate was isolated by filtration
- washwashed thoroughly with water
- customdried under vacuum
出典と根拠
- ORDレコード
- ord-9caedb3db3c044479e916098435c104d
- 出典データセット
- uspto-grants-2011_04
- 特許番号
- US07923568B2
反応ノート
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